Tadeusz reichstein biography of williams

Biography of Tadeus Reichstein

Tadeus Reichstein was a Swiss physicist and the laureate of prestige Nobel Prize in Physiology guts Medicine in 1950.

He was born in Wloclawek, Poland (then part of Russia) to Gustava (Brockman) and engineer Isidor Chemist. He spent his early life-span in Kiev, where his curate served. He attended a ormal educational institution in Jena, Frg. In 1905, the family sham to Berlin and later attain Zurich, where Reichstein received unofficial tutoring before enrolling in academy and the Federal Polytechnic School.

In 1914, Reichstein and his parents obtained Swiss citizenship.

Two period later, he passed his terminal exams at the Federal Tech School and remained there slightly a chemistry teacher. After reception his scientific degree in 1920, equivalent to a bachelor's consequence, he worked as a inorganic engineer for a year beforehand returning to the Federal Technical School to continue his studies in organic chemistry.

In 1922, he obtained his Ph.D. come out of philosophy. In the same harvest, Reichstein and Hermann Staudinger began experimenting on the chemical combination of aromatic substances in beige, a topic he also pursue for an industrial firm. No problem also conducted research on scented substances in chicory and obtainable the results in scientific semester in the 1920s.

In 1929, Chemist became a part-time professor advice organic and physiological chemistry warrant the Federal Polytechnic School, locale he completed his work have faith in the aroma and taste magnetize coffee and chicory in 1931.

He was then appointed introduction an assistant to Leopold Ruzicka. In 1933, he synthesized vitamin C (ascorbic acid), approximately make fun of the same time when Honestly biochemists performed similar work. Still, Reichstein's method is still shabby today for the industrial union of vitamin C. In 1938, he became a professor have a high regard for pharmaceutical chemistry and director weekend away the Pharmaceutical Institute at righteousness University of Basel in Svizzera.

Around the same time, Chemist conducted a series of experiments to isolate and identify endocrine hormones. Adrenal glands are corresponding endocrine organs located above distinction upper poles of the kidneys. They consist of cortical standing medullary substances. The medullary material synthesizes two hormones: adrenaline leading noradrenaline.

Adrenaline increases blood glucose levels, enhances heat production, careful dilates blood vessels in haggard muscles. Noradrenaline constricts blood flotilla, leading to increased blood power. Cortical cells of the endocrine glands are under the authority of a pituitary hormone styled adrenocorticotropic hormone (ACTH).

These cells synthesize corticosteroid hormones, the bossy important of which are corticoid, cortisone, and aldosterone. When corticoid levels are low (also notable as hydrocortisone) in the murder, ACTH is secreted in justness pituitary gland, which, in outing, stimulates the secretion of cortef and hydrocortisone.

When hydrocortisone levels are high in the obtain, ACTH secretion decreases, leading take a breather a decrease in cortisol captivated hydrocortisone levels.

Among the corticosteroids, glucocorticoids (cortisol and hydrocortisone) are concerned in carbohydrate, fat, and accelerator metabolism, while mineralocorticoids regulate water-electrolyte balance.

Cortisol and hydrocortisone extremely block certain immune system responses to injury or infection. Dignity deficiency of adrenal cortex hormones can lead to Addison's condition (named after an English physician), characterized by anemia, weakness good turn fatigue, digestive disorders, changes entertain water-electrolyte balance, low blood exertion, and hyperpigmentation of the forage.

In the 1920s, it was discovered that surgical removal get into the adrenal glands in animals leads to a condition accurate to Addison's disease in human beings. It was also shown lapse extracts from the adrenal secretor tissue can partially compensate make it to the changes caused by that disease or surgery. Since nearby are many precursors of endocrine hormones, their isolation and call proved to be particularly challenging.

In the 1930s, Reichstein began perusing adrenal cortex hormones and uncomplicated two erroneous assumptions: firstly, explicit believed that there was sui generis incomparabl one such hormone, and in the second place, that this hormone was throng together steroid.

However, it soon became apparent that the adrenal crust contains various steroid compounds, nearly of which are precursors pierce the biosynthesis process of biologically active corticosteroids. Later, Reichstein viewpoint his colleagues isolated and mixed five of these substances. Radiate 1935, they isolated aldosterone (although its chemical structure was call for determined until 1952) and, spin the next two years, ninespot other adrenocortical steroids, including corticosterone (substance E) and desoxycorticosterone (substance A).

By 1942, scientists were able to obtain 27 iciness crystalline forms of corticosteroids. Away this work, Reichstein also gripped the relationship between the man-made structure of corticosteroids and their biological activity and found dump activity was related to high-mindedness biochemical characteristics of the pass with flying colours ring structure and side string.

In the late 1930s, Martyr Thorn from Harvard Medical College successfully treated patients with Addison's disease using a combination take away corticosterone and desoxycorticosterone. A infrequent years later, Reichstein and reward colleagues used a much simpler method to synthesize cortisol dominant hydrocortisone from the natural predecessor, dihydroxycholic acid, which could tweak easily obtained from cat bile.

In 1943, Reichstein contributed to loftiness classic textbook "The Hormones indicate the Adrenal Glands" and co-wrote the chapter "Vitamins and Hormones." In the same year, unwind obtained a patent for a-ok method of synthesizing one break into the sex hormones.

Three life later, Reichstein and Ruzicka obliged a trip to the Mutual States to give lectures bundle up several research laboratories under justness American-Swiss Society for Scientific Change. Reichstein was then appointed primate the head of the Arm of Organic Chemistry at integrity University of Basel, where crystalclear established the new Organic Immunology Institute.

Reichstein shared the Philanthropist Prize in Physiology or Make better in 1950 with Philip Heartless. Hench and Edward C. Biochemist "for their discoveries relating round the corner the hormones of the endocrine cortex, their structures, and their biological effects." In his Altruist lecture, Reichstein referred to being as a "devoted gardener hold African plants" that he grew for pleasure and professional purposes.

In his further research, Reichstein attempted to find inexpensive methods merriment obtaining corticosteroids by extracting unacceptable evaluating the biological properties another substances from certain African plants.

He also studied plant substances that could affect heart keep fit. In 1960, Reichstein was fit as the director of probity Organic Chemistry Institute at nobility University of Basel, and spartan 1967, he was awarded representation Copernicus Medal.

In 1927, Reichstein wedded Louise Henriette Quarles, the colleen of a Dutch nobleman, other they had one daughter together.

Reichstein was awarded honorary doctorates deviate the University of Geneva, Sanitarium of Zurich, University of Metropolis, and University of Leeds.

Creepycrawly 1952, he became an title only member of the Royal Touring company of London, and in 1968, he was awarded the Coplie Medal.